Delineating the "galectin signature" of the tumor microenvironment
نویسندگان
چکیده
Galectins, a family of glycan-binding proteins, can control tumor progression by promoting transformation, angiogenesis and immune escape. We identified a dynamically regulated 'galectin signature', which delineates the progression of prostate cancer, highlighting galectin-1 as an attractive target for anti-angiogenic therapy in advanced stages of the disease.
منابع مشابه
A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease.
Galectins, a family of glycan-binding proteins, influence tumor progression by modulating interactions between tumor, endothelial, stromal, and immune cells. Despite considerable progress in identifying the roles of individual galectins in tumor biology, an integrated portrait of the galectin network in different tumor microenvironments is still missing. We undertook this study to analyze the "...
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013